A drop of human blood is presumed to have 1011 specific antibodies that recognize different immunogens (natural antigen epitopes and antigenic mimics, mimotopes). Although the potential size of the human immunoglobulin repertoire has been estimated, the understanding of its overall involvement in the immune response has remained elusive, mainly because we are not yet able to decipher it. MVA technology has overcome that problem. Protobios' novel technology platform, Mimotope Variation Analysis (MVA, patent pending), for parallel and quantitative profiling of the binding specificity, versatility and biological activity of millions of antibodies, reflects the total immune response.
MVA technology enables to obtain quantitative and qualitative antibody binding profiles (immunoprofiles). A binding profile can be made to describe a single molecule up to individuals or populations. An immunoprofile describes the state of the immune system and its ability to protect the body. That is considered an innovative tool interpreting health related data for diseases; health conditions and propels the caregivers towards a new level of understanding regarding the prevention and treatment. Also MVA allows offering reliable services such as epitope mapping, antibody analyses, immunogenicity assessment etc. to research groups and biotechnology industry.
MVA technology is based on screening of combinatorial peptide display library, next generation DNA sequencing and proprietary bioinformatics analysis.