Our Publications

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling.
Sadam H, Pihlak A, Kivil A, Pihelgas S, Jaago M, Adler P, Vilo J, Vapalahti O, Neuman T, Lindholm D, Partinen M, Vaheri A, Palm K (2018).
Human picornaviruses associated with neurological diseases and their neutralization by antibodies.
Anastasina M, Domanska A, Palm K, Butcher S. (2017).
Biosynthesis of Trehangelin in Polymorphospora rubra K07–0510: Identification of Metabolic Pathway to Angelyl-CoA.
Inahashi, Y., Shiraishi, T., Palm, K., Takahashi, Y., Ōmura, S., Kuzuyama, T., Nakashima, T.. (2016).
Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour.
Kazantseva, J., Ivanov, R., Gasik, M., Neuman, T., & Hussainova, I. (2016).
Targeted alternative splicing of TAF4: A new strategy for cell reprogramming.
Kazantseva, J., Sadam, H., Neuman, T., Palm, K. (2016).
Mimotope variance analysis: A novel immunoprofiling method to monitor progression of cervical cancer.
Enerly, E., Nygård, M., Orumaa, M., Pihlak, A., Pihelgas, S., Langseth, H., Neuman, T., Palm K. (2016).
Auxiliary Biomembranes as a Directional Delivery System To Control Biological Events in Cell-Laden Tissue-Engineering Scaffolds.
Helena Knopf-Marques, Julien Barthes, Lucie Wolfova, Berenge ́ re Vidal, Geraldine Koenig, Jalal Bacharouche, Gregory Francius, Helle Sadam, Urmas Liivas, Philippe Lavalle, and Nihal Engin Vrana. 2017.
Controlling Incoming Macrophages to Implants: Responsiveness of Macrophages to Gelatin Micropatterns under M1/M2 Phenotype Defining Biochemical Stimulations.
Camille Dollinger, Albana Ndreu-Halili, Arban Uka, Sonali Singh, Helle Sadam, Toomas Neuman, Morgane Rabineau, Philippe Lavalle, Mehmet R. Dokmeci, Ali Khademhosseini, Amir M. Ghaemmaghami, and Nihal E. Vrana. 2017.
Diagnostic significance of alternative splice variants of REST and DOPEY1 in the peripheral blood of patients with breast cancer.
Lend, A.K., Kazantseva, A., Kivil, A. et al. (2015).
LXXLL Peptide Converts Transportan 10 to a Potent Inducer of Apoptosis in Breast Cancer Cells.
Tints, K., Prink, M., Neuman, T., & Palm, K. (2014).
Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells.
Piirsoo, A., Kasak, L., Kauts, M.-L., Loog, M., Tints, K., Uusen, P., Piirsoo, M. (2014). .
Diversity in TAF Proteomics: Consequences for Cellular Differentiation and Migration.
Kazantseva, J., & Palm, K. (2014).
CCL5/CCR1 axis regulates multipotency of human adipose tissue derived stromal cells.
Kauts, M., Neuman, T., Orro, K., Pihelgas, S., & Piirsoo, A. (2013).
Alternative Splicing Targeting the hTAF4-TAFH Domain of TAF4 Represses Proliferation and Accelerates Chondrogenic Differentiation of Human Mesenchymal.
Kazantseva J, Kivil A, Tints K, Kazantseva A, Neuman T, Palm K (2013).
RNA-Seq Analysis Reveals Different Dynamics of Differentiation of Human Dermis- and Adipose-Derived Stromal.
Jääger, K., Islam, S., Linnarsson, S., Neuman, T., & Zajac, P. (2012).
Human Dermal Fibroblasts Exhibit Delayed Adipogenic Differentiation Compared with Mesenchymal Stem Cells.
Jääger, K., Neuman, T. (2011).
Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.
Helle Sadam, Arno Pihlak, Mariliis Jaago, Nadežda Pupina, Annika Rähni, Maarja Toots, Antti Vaheri, Janne K Nieminen, Mika Siuko, Pentti J Tienari, Kaia Palm (2021)
Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.
Nadežda Pupina, Annela Avarlaid, Helle Sadam, Arno Pihlak, Mariliis Jaago, Jürgen Tuvikene, Annika Rähni, Anu Planken, Margus Planken, Eija Kalso, Pentti J. Tienari, Janne K. Nieminen, Mikko R.J. Seppänen, Antti Vaheri, Dan Lindholm, Juha Sinisalo, Pirkko Pussinen, Tõnis Timmusk, Kaia Palm (2022)
Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.
Annika Rähni, Mariliis Jaago, Helle Sadam, Nadežda Pupina, Arno Pihlak, Jürgen Tuvikene, Margus Annuk, Andrus Mägi, Tõnis Timmusk, Amir M Ghaemmaghami, Kaia Palm (2022)
Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.
Mariliis Jaago, Annika Rähni, Nadežda Pupina, Arno Pihlak, Helle Sadam, Jürgen Tuvikene, Annela Avarlaid, Anu Planken, Margus Planken, Liina Haring, Eero Vasar, Miljana Baćević, France Lambert, Eija Kalso, Pirkko Pussinen, Pentti J Tienari, Antti Vaheri, Dan Lindholm, Tõnis Timmusk, Amir M Ghaemmaghami, Kaia Palm (2022)
Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease.
Mariliis Jaago, Nadežda Pupina, Annika Rähni, Arno Pihlak, Helle Sadam, Nihal Engin Vrana, Juha Sinisalo, Pirkko Pussinen, Kaia Palm (2022)

Defended academic degrees

Differentiation and Heterogeneity of Mesenchymal Stem Cells
Kersti Jääger (2013)
Alternative Splicing of TAF4: A Dynamic Switch between Distinct Cell Functions
Jekaterina Kazantseva (2014)
Alternative Splicing in Health and Disease
Anna Kazantseva (2016)
Immunodominant Antibody Epitopes Associated with the Development of Multiple Sclerosis and Type 1 Narcolepsy – A Next-Generation Phage-Display Analysis.
Helle Sadam (2022)

Organized Events


Pentti Tienari visit

In October 2018 the laboratories of Protobios were visited by leading Multiple sclerosis practicing MD and principal investigator from the University of Helsinki Prof Pentti Tienari and his lab technician Lilja Jansson. The visit was performed within the SZTest project. Our honourable guests shared their knowledge in field of neuro-immunology and introduced relevant advanced methods.

Nobel Prize for phage display

The Nobel Prize in Chemistry 2018 was assigned to George P. Smith and Sir Gregory P. Winter for the invention of phage display of peptides and antibodies, as well as Frances H. Arnold for the directed evolution of enzymes. These two powerful methods of screening are fundamentally used in manufacturing and drug development, including our labs!